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Neural Foundry's avatar

Great perspective on the histamine angle. The tolerance reset theory makes alot of sense from a receptor sensitivity standpoint - I've noticed similar patterns when cycling off certain supplements. That HUNT study finding about fitness being a stronger predictor than drinking patterns is kinda wild tho.

Kate Reuschel's avatar

Interesting. I’ve had a super low tolerance for alcohol my entire life. One beer, 1-2 glasses of wine max and drunk. Then after chemo and not drinking for over a year it was about 3 sips and tipsy. No one believed me until they witnessed it in person. Now I am back to my 1-2 glasses of wine max, but I can’t drink a glass nightly and do have to mind my heart medication and heart rate when drinking now. There are definitely health reasons for drinking less or not drinking. And I love your histamine part. I have so many allergies since chemo. My list is so long I forget, but I am finding I have had to take some of my favorite foods out of my diet because they trigger huge histamine reaction or an intolerance inflammation reaction.

Michael Boyne's avatar

Nice article mate. I’ll be interested to see if your experiment in managing your tolerance works out. I’ve dramatically reduced the amount I drink (for the calorific reasons you mention) but I’ve found on the odd occasion I do go ‘out’ out my tolerance is still where it always was. Could be because I’ve never gone as far as full abstinence; I have a drink when I genuinely ‘want’ one as opposed to just thoughtlessly opening a bottle every night like I used to. I can’t quite bring myself to call it ‘mindful drinking’ but if it walks like a duck and quacks like a duck…

Sophia Williams's avatar

Really interesting read, Dan. I'm doing something similar from a different angle. Following The Diet Whisperer approach to shift from burning carbs to fat, specifically targeting visceral fat rather than weight loss per se.

What's genuinely surprised me is how the energy slumps have vanished. After just a week, those mid-morning and afternoon crashes completely disappeared. It's remarkable how much our fuel source affects daily energy levels.

Your histamine journey sounds challenging. All the delicious foods being off-limits is frustrating: wine, aged cheese, sourdough. I love that you're taking such a systematic approach to the experiment. The tolerance reset theory is intriguing too. Would be really interested to hear how February goes.

Hope the reset gives you the answers you're looking for, and you're back to pizza and wine soon!

Aleksandar Draganic's avatar

The connection between histamine and fermented favorites like wine and cheese is so often overlooked. It's tough when 'all the nice things' are the culprits, but it’s fascinating how quickly the body responds once you clear that overload. Your 'sick dog' diet of chicken and rice is definitely a commitment, but feeling better is a pretty compelling reason to stick with it. Great to see this specific angle highlighted!